diff --git a/README.md b/README.md
index 7f084e64..a064978f 100644
--- a/README.md
+++ b/README.md
@@ -406,6 +406,7 @@ See code for all available configurations.
 | [System76 Darter Pro 6](system76/darp6)                                           | `<nixos-hardware/system76/darp6>`                       | `system76-darp6`|
 | [System76 Gazelle 18](system76/gaze18)                                            | `<nixos-hardware/system76/gaze18>`                      | `system76-gaze18`|
 | [System76 Galago Pro 5](system76/galp5-1650)                                      | `<nixos-hardware/system76/galp5-1650>`                  | `system76-galp5-1650`|
+| [System76 Thelio Mega](system76/thelio-mega)                                      | `<nixos-hardware/system76/thelio-mega>`                 | `system76-thelio-mega`|
 | [Toshiba Chromebook 2 `swanky`](toshiba/swanky)                                   | `<nixos-hardware/toshiba/swanky>`                       | `toshiba-swanky`|
 | [Tuxedo InfinityBook v4](tuxedo/infinitybook/v4)                                  | `<nixos-hardware/tuxedo/infinitybook/v4>`               | `tuxedo-infinitybook-v4`|
 | [TUXEDO Aura 15 - Gen1](tuxedo/aura/15/gen1)                                      | `<nixos-hardware/tuxedo/aura/15/gen1>`                  | `tuxedo-aura-15-gen1`|
diff --git a/flake.nix b/flake.nix
index 0a0a749d..a0ac1fb8 100644
--- a/flake.nix
+++ b/flake.nix
@@ -348,6 +348,7 @@
           system76-gaze18 = import ./system76/gaze18;
           system76-galp5-1650 = import ./system76/galp5-1650;
           system76-darp6 = import ./system76/darp6;
+          system76-thelio-mega = import ./system76/thelio-mega;
           toshiba-swanky = import ./toshiba/swanky;
           tuxedo-aura-15-gen1 = import ./tuxedo/aura/15/gen1;
           tuxedo-infinitybook-v4 = import ./tuxedo/infinitybook/v4;
diff --git a/system76/thelio-mega/default.nix b/system76/thelio-mega/default.nix
new file mode 100644
index 00000000..b88f1366
--- /dev/null
+++ b/system76/thelio-mega/default.nix
@@ -0,0 +1,16 @@
+# Hardware profile for the Thelio Mega desktop workstation by System76.
+#
+# https://system76.com/desktops/thelio-mega-r4-n3/configure
+{
+  config,
+  lib,
+  ...
+}:
+{
+  imports = [
+    ../../common/cpu/amd
+    ../../common/gpu/nvidia
+  ];
+
+  hardware.nvidia.open = true;
+}